mRNA cancer vaccine succeeded in Phase 3 melanoma trial, Moderna and Merck say

mRNA cancer vaccine succeeded in Phase 3 melanoma trial, Moderna and Merck say

fivenewscrypto    août 21, 2026   

Pharmaceutical partners Moderna and Merck announced on Wednesday that their novel mRNA-based vaccine—individually tailored to target a patient's unique cancer mutations—was effective in a late-stage clinical trial of patients with melanoma, one of the deadliest forms of skin cancer.

The announcement was scant on details, but if the success holds, it stands to realize the high aspirations for both mRNA vaccines and individualized cancer-targeting medicines in cancer therapy, providing a first success for both treatment types.

The Phase 3 trial included 1,137 patients who had stage IIB–IV melanoma that had been surgically removed prior to their treatment in the trial. Patients were randomized 2-1 to receive either a combination treatment of the tailored mRNA vaccine (intismeran or mRNA-4157) with Merck's established monoclonal antibody cancer treatment Keytruda, or they received treatment with Keytruda alone. Both patient groups were treated for about a year. The trial was placebo-controlled and double-blind, meaning neither the doctors nor the patients knew which treatment patients were randomly assigned to receive.

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Google Pixel 11 series review: Is the magic fading?

Google Pixel 11 series review: Is the magic fading?

fivenewscrypto    août 21, 2026   

Google's approach to making smartphones has changed a lot over the years. It started with Nexus phones aimed at the tinkerer and enthusiast niche back when there were countless companies making smartphones. Today, there are far fewer, and Google's hyper-polished Pixel lineup is seeing less competition and higher sales. So maybe Google thinks it can just keep doing what works. The new Pixel 11 series is Google's most refined yet, featuring sleek designs, smart software, and incredible screens. They're also rather boring.

Google made precious few hardware changes in its 2026 phones, shaving off a fraction of a millimeter here and dropping a gram there. The design language has been the same now for three generations, all while prices continue to inch upward. And this year, Google's hardware has actually regressed in a few key areas. Despite that, the Pixel 11 phones aren't bad—they're some of the best 2026 has to offer. But it feels like Google is forgetting that it's not just competing against Apple and Samsung. It also has to compete against the Pixels of yesteryear.

The same old (but great) design

Just like last year's Pixel 10 series, Google's 2026 lineup includes three flat phones and one foldable. The flat Pixels are the same size, and even side-by-side, it's hard to tell them apart from their predecessors. We've got almost identical aluminum and glass sandwich designs, which do admittedly look very nice. They still have Pixelsnap, too.

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Scientists find closest star to the Milky Way's central black hole

Scientists find closest star to the Milky Way's central black hole

fivenewscrypto    août 20, 2026   

Sgr A* is the name we've given to the supermassive black hole that sits at the center of the Milky Way. We've known about its presence since the 1970s but only managed to image it within the past few years. In the intervening time, most of our understanding of the object was obtained by watching a group of stars that orbit the black hole, helping us get a good estimate of its mass and size. In essence, those stars acted as instruments that let us peer into an environment we couldn't study any other way.

In Wednesday's issue of Nature, researchers describe a recently discovered star that is on an extremely eccentric orbit that takes it closer to Sgr A* than anything we've previously identified. It gets so close that it may help us get our first measurements of the spin of the black hole.

Reading the spin

There's an entire population of stars that orbit relatively close to Sgr A*. We can estimate their mass based on their brightness and spectral features. Using their masses and a reconstruction of their orbits using several years of data, we can figure out just how supermassive Sgr A* is (nearly 10³⁷ kilograms).

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Meta ran ads for an app promising to nudify female politicians

Meta ran ads for an app promising to nudify female politicians

fivenewscrypto    août 20, 2026   

Meta platforms recently ran ads for an AI porn-generation tool that seemingly encouraged users to create deepfaked videos resembling female US politicians, despite the company’s policies against ads containing sexual material. It’s the latest in a series of failures by Meta to keep advertisements for tools that produce nonconsensual intimate imagery off its platforms.

The tool, which is called Kromix, bills itself as an “AI image styler.” A voice-over for one of the video advertisements, viewed by WIRED, promotes the tool as having “no restrictions,” saying “all the characters are real people” and describing it as “the AI that men actually use.” In one ad, a woman closely resembling a prominent female US politician is seen in front of a US flag and the flag of the president of the US above the caption “What if she moved?” She then winks, before the ad cuts to a scene of a woman with the same face performing in a pornographic video.

The Kromix app, which was hosted by Apple’s App Store prior to a request for comment from WIRED, invites paid users to upload photos so that it can use them in scenarios including “bedroom rape” and “Disney love.” Videos on the app also feature AI-generated pornographic videos of women wearing Spider-Man costumes. Requests for comment sent to a contact listed in the app went unanswered.

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Trump expected to pick conservative policy wonk Heidi Overton to lead FDA

Trump expected to pick conservative policy wonk Heidi Overton to lead FDA

fivenewscrypto    août 20, 2026   

President Trump is expected to nominate Heidi Overton, a top conservative policy aide, as the next commissioner of the Food and Drug Administration, according to multiple media reports.

Overton is currently the deputy director of the White House Domestic Policy Council and has played a key role in shaping a variety of health policies during Trump's second term. At times, she has notably angered members of the Make America Healthy Again movement, which was created by anti-vaccine Health Secretary Robert F. Kennedy Jr.

Overton has a medical degree from the University of New Mexico School of Medicine and earned a doctoral degree in clinical investigation from Johns Hopkins Bloomberg School of Public Health. While at Johns Hopkins, she worked with Marty Makary, the previous FDA commissioner who was ousted by Trump amid a cacophony of controversies.

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"Sabotage": Experts, lawmakers blast RFK Jr. for destroying healthcare research

"Sabotage": Experts, lawmakers blast RFK Jr. for destroying healthcare research

fivenewscrypto    août 20, 2026   

The federal agency tasked with studying ways to improve America's outstandingly poor healthcare system is "on the brink," experts warn. The Trump administration has cut its staff by 75 percent, canceled its grants en masse, and is refusing to spend tens of millions of dollars appropriated by Congress.

Whether the agency "will survive the second Trump administration is an open question," health policy experts Aaron Carroll and David Atkins wrote in an opinion piece published today in the Annals of Internal Medicine.

The agency in question is the Agency for Healthcare Research and Quality (AHRQ), which has focused on ways to improve patient safety, healthcare quality, care delivery, and new technologies and practices since the 1990s. In the past, "Republican leaders recognized that health care disparities were fundamental quality problems," Carroll and Atkins wrote. But recently, disparities in care have become partisan issues.

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Ukrainian drones overwhelm Russian tanks’ new active protection system—for now

Ukrainian drones overwhelm Russian tanks’ new active protection system—for now

fivenewscrypto    août 20, 2026   

Russian tanks have entered battle for the first time with a new active protection system designed to shoot down incoming drones. But the technology’s recent combat debut in Ukraine met with only limited success—Ukrainian drones still destroyed the Russian armored vehicles by attacking in overwhelming numbers.

The first documented battlefield appearance of the Arena-M active protection system took place when Russian forces launched a company-size assault with tanks and other armored vehicles in the Donetsk Oblast region of eastern Ukraine on July 22. The Ukrainian defenders repelled the attack and posted video footage of their kamikaze drone strikes destroying at least seven T-72B3A tanks, including some that carried the Arena-M system, according to Euromaidan Press.

However, Ukrainian soldiers also described the Russian Arena-M system successfully shooting down some incoming drones, according to the journalists Dmytro Putiata and Rob Lee. The Ukrainians reported requiring between 15 and 20 drones to finish off each tank.

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